Smoking Doubles Risk of Alzheimer's Disease 1. November 2010 0 (0) Smoking more than doubles your odds of developing Alzheimer's disease, a Kaiser Permanente study found. The researchers separated vascular dementia from Alzheimer's disease. From 1994 to 2008, researchers evaluated the records of 21,123 men and women in midlife and continued following them, on average, for 23 years. Compared with non-smokers, those who had smoked two packs of cigarettes a day increased their risk of developing Alzheimer's disease by more than 157%. They also had a 172% higher risk of developing vascular dementia — the second most common form of dementia after Alzheimer's. The research is published in the Archives of Internal Medicine. Another good reason to quit smoking. Learn more about dementia and ways to interact with seniors with memory loss as a senior caregiver.